Fluorescent sialic derivatives for the specific detection of influenza viruses

Dandan Liu; Xikai Cui; Abasaheb N Dhawane; Vasanta Chivukula; Suri S Iyer

doi:10.1016/j.bmcl.2019.126773

Fluorescent sialic derivatives for the specific detection of influenza viruses

Bioorg Med Chem Lett. 2019 Dec 15;29(24):126773. doi: 10.1016/j.bmcl.2019.126773. Epub 2019 Oct 31.

Authors

Dandan Liu¹, Xikai Cui¹, Abasaheb N Dhawane¹, Vasanta Chivukula², Suri S Iyer³

Affiliations

¹ 788 Petit Science Center, Department of Chemistry, Centre for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States.
² Atlanta Metropolitan State College, 1630 Metropolitan Parkway, Atlanta, GA 30310, United States.
³ 788 Petit Science Center, Department of Chemistry, Centre for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States. Electronic address: siyer@gsu.edu.

PMID: 31718863
DOI: 10.1016/j.bmcl.2019.126773

Abstract

Early and accurate diagnosis of influenza viruses can decrease its harmful impact. Here, we have synthesized fluorescent sialic acid derivatives that are cleaved by influenza neuraminidases (NAs) and not by Streptococcus pneumoniae that also inhabits the human olfactory. We have also attempted to develop assays that could differentiate between influenza virus and S. pneumoniae by taking advantage of the structural differences between NAs from these pathogens.

Keywords: Glycan; Influenza; Neuraminidase; Sialic acid; Streptococcus pneumoniae.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Humans
N-Acetylneuraminic Acid / metabolism*
Neuraminidase / metabolism*
Orthomyxoviridae / pathogenicity*

Substances

Neuraminidase
N-Acetylneuraminic Acid