[Whether lowering intraocular pressure is needed for thyroid associated ophthalmopathy with intraocular hypertension]

Zhonghua Yan Ke Za Zhi. 2019 Nov 11;55(11):811-813. doi: 10.3760/cma.j.issn.0412-4081.2019.11.004.
[Article in Chinese]

Abstract

Patients with thyroid associated ophthalmopathy often have elevated intraocular pressure. Patients and doctors are often confused about whether intraocular hypertension in thyroid associated ophthalmopathy needs to be lowered. There are several theories on the possible causes of this kind of increased intraocular pressure: restriction and compression of the globe by fibrotic and enlarged rectus muscles, increased episcleral venous pressure resulting from orbital congestion and venous outflow obstruction, and increased resistance to trabecular outflow. In addition, the patient's eye position and the device for measuring intraocular pressure also have great impacts on the accuracy of intraocular pressure measurement. At the same time, there are very few patients with thyroid associated ophthalmopathy combined with primary glaucoma. Therefore, whether patients with elevated intraocular pressure need to be treated depends on the specific clinical manifestations of the thyroid associated ophthalmopathy. Intraocular pressure of most patients can be lowered by active treatment for thyroid associated ophthalmopathy; antiglaucoma medical therapy may be necessary for patients whose intraocular pressure cannot be lowered; only very few cases of glaucoma require antiglaucoma drugs or surgery. (Chin J Ophthalmol, 2019, 55:811-813).

甲状腺相关眼病(TAO)常伴发高眼压,发生机制复杂,包括肥大水肿的眼外肌压迫眼球壁;眶内结缔组织及眼肌肥大水肿使眶压增加,导致房水静脉压升高,房水流出阻力增加等。此外,测量眼压的眼位及使用的仪器对眼压测量的精准度也有较大影响。同时,极少数TAO患者合并原发性青光眼。TAO高眼压是否需要降眼压治疗,本文在分析高眼压发生机制的基础上,提出应针对TAO的临床表现和特点制定不同的治疗策略,以获得最佳临床疗效。(中华眼科杂志,2019,55:811-813).

Keywords: Clinical protocols; Glaucoma; Graves ophthalmopathy; Ocular hypertension.

MeSH terms

  • Graves Ophthalmopathy / complications*
  • Graves Ophthalmopathy / therapy
  • Humans
  • Intraocular Pressure*
  • Ocular Hypertension / therapy*
  • Tonometry, Ocular