International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass

B Hasse; M M Hannan; P M Keller; F P Maurer; R Sommerstein; D Mertz; D Wagner; N Fernández-Hidalgo; J Nomura; V Manfrin; D Bettex; A Hernandez Conte; E Durante-Mangoni; T H-C Tang; R L Stuart; J Lundgren; S Gordon; M C Jarashow; P W Schreiber; S Niemann; T A Kohl; C L Daley; A J Stewardson; C J Whitener; K Perkins; D Plachouras; T Lamagni; M Chand; T Freiberger; S Zweifel; P Sander; B Schulthess; J E Scriven; H Sax; J van Ingen; C A Mestres; D Diekema; B A Brown-Elliott; R J Wallace Jr; L M Baddour; J M Miro; B Hoen; M. chimaera ISCVID Investigators and; ISCVID Executive Committee; E Athan; A Bayer; B Barsic; G R Corey; V H Chu; D T Durack; C Q Fortes; V Fowler; B Hoen; A W Krachmer; E Durante-Magnoni; J M Miro; W R Wilson; Infectious Diseases Specialists; Hospital Epidemiologists; Microbiologists and Molecular Typing Specialists; Cardiac Surgeons/ Perfusionists/ Cardiologists; Ophthalmology; Anaesthesiologists; Public Health

doi:10.1016/j.jhin.2019.10.009

International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass

J Hosp Infect. 2020 Feb;104(2):214-235. doi: 10.1016/j.jhin.2019.10.009. Epub 2019 Nov 9.

Authors

B Hasse¹, M M Hannan², P M Keller³, F P Maurer⁴, R Sommerstein⁵, D Mertz⁶, D Wagner⁷, N Fernández-Hidalgo⁸, J Nomura⁹, V Manfrin¹⁰, D Bettex¹¹, A Hernandez Conte¹², E Durante-Mangoni¹³, T H-C Tang¹⁴, R L Stuart¹⁵, J Lundgren¹⁶, S Gordon¹⁷, M C Jarashow¹⁸, P W Schreiber¹⁹, S Niemann²⁰, T A Kohl²⁰, C L Daley²¹, A J Stewardson²², C J Whitener²³, K Perkins²⁴, D Plachouras²⁵, T Lamagni²⁶, M Chand²⁷, T Freiberger²⁸, S Zweifel²⁹, P Sander³⁰, B Schulthess³¹, J E Scriven³², H Sax¹⁹, J van Ingen³³, C A Mestres³⁴, D Diekema³⁵, B A Brown-Elliott³⁶, R J Wallace Jr³⁶, L M Baddour³⁷, J M Miro³⁸, B Hoen³⁹; M. chimaera ISCVID Investigators and; ISCVID Executive Committee; E Athan⁴⁰, A Bayer⁴¹, B Barsic⁴², G R Corey⁴³, V H Chu⁴⁴, D T Durack⁴⁴, C Q Fortes⁴⁵, V Fowler⁴⁶, B Hoen⁴⁷, A W Krachmer⁴⁸, E Durante-Magnoni⁴⁹, J M Miro⁵⁰, W R Wilson⁵¹; Infectious Diseases Specialists; Hospital Epidemiologists; Microbiologists and Molecular Typing Specialists; Cardiac Surgeons/ Perfusionists/ Cardiologists; Ophthalmology; Anaesthesiologists; Public Health

Collaborators

L M Baddour⁵², D Diekema⁵³, N Fernández-Hidalgo⁵⁴, S Gordon¹⁷, B Hasse¹⁹, J Lundgren¹⁶, V Manfrin⁵⁵, J Nomura⁵⁶, J Scriven⁵⁷, R Stewart¹⁵, D Wagner⁵⁸, T H-C Tang⁵⁹, L A Herwaldt⁶⁰, D Mertz⁶, H Sax¹⁹, P Schreiber¹⁹, R Sommerstein⁶¹, A Stewardson⁶², C J Whitener²³, A Widmer⁶³, B A Brown Elliot³⁶, C Daley²¹, T Freiberger²⁸, J van Ingen⁶⁴, P Keller⁶⁵, T A Kohl⁶⁶, F Maurer⁶⁷, S Niemann⁶⁸, R J Wallace Jr³⁶, V Falk⁶⁹, M Halbe⁷⁰, C A Mestres⁷¹, S Zweifel⁷¹, D Bettex⁷², A Hernandez Conte⁷³, M Chand⁷⁴, M C Jarashow¹⁸, T Lamagni⁷⁵, D Plachouras¹⁸, K M Perkins⁷⁶

Affiliations

¹ Division of Infectious Diseases and Hospital Epidemiology, University Hospital and University of Zurich, Switzerland. Electronic address: barbara.hasse@usz.ch.
² Clinical Microbiology, Mater Misericordiae University Hospital, Dublin, Ireland.
³ Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
⁴ Diagnostic Mycobacteriology Group, National and WHO Supranational Reference Center for Mycobacteria, Research Center, Borstel, Germany.
⁵ Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
⁶ Departments of Medicine, Health Research Methods, Evidence and Impact, and Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
⁷ Department of Internal Medicine II, Division of Infectious Diseases, Medical Center - University of Freiburg, Freiburg i.Br, Germany.
⁸ Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
⁹ Kaiser Permanente Infectious Diseases, Los Angeles Medical Center, CA, USA.
¹⁰ Infectious and Tropical Diseases Department, San Bortolo Hospital, Vincenca, Italy.
¹¹ Institute of Anesthesiology, University Hospital Zurich, Switzerland.
¹² Department of Anaesthesiology, Kaiser Permanente, Los Angeles Medical Center, CA, USA.
¹³ Infectious and Transplant Medicine, University of Campania 'L. Vanvitelli', Monaldi Hospital, Naples, Italy.
¹⁴ Division of Infectious Diseases, Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China.
¹⁵ Monash Infectious Diseases, Monash Health, Australia.
¹⁶ Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark.
¹⁷ Department of Infectious Diseases, Cleveland Clinic, OH, USA.
¹⁸ Acute Communicable Disease Control, Los Angeles Department of Public Health, LA, USA.
¹⁹ Division of Infectious Diseases and Hospital Epidemiology, University Hospital and University of Zurich, Switzerland.
²⁰ Molecular and Experimental Mycobacteriology Group, Research Center Borstel, Borstel, Germany and German Center for Infection Research (DZIF), partner site Hamburg - Lübeck - Borstel - Riems, Borstel, Germany.
²¹ Division of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, CO, USA.
²² Department of Infectious Diseases, The Alfred and Central Clinical School, Monash University, Melbourne, Australia.
²³ Penn State Health, Milton S. Hershey Medical Center, Hershey, PA, USA.
²⁴ Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, USA.
²⁵ Healthcare-associated Infections, European Centre for Disease Prevention and Control (ECDC), Solna, Sweden.
²⁶ National Infection Service, Public Health England, London, UK.
²⁷ National Infection Service, Public Health England, London, UK; Guy's and St Thomas' NHS Foundation Trust, Imperial College London, UK.
²⁸ Centre for Cardiovascular Surgery and Transplantation, Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
²⁹ Ophthalmology Unit, University of Zurich, Switzerland.
³⁰ National Center for Mycobacteria, Zurich, Switzerland, Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
³¹ Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
³² Department of Infection and Tropical Medicine, University Hospitals Birmingham, Birmingham, UK.
³³ Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.
³⁴ Clinic for Cardiovascular Surgery, University Hospital and University of Zurich, Switzerland.
³⁵ Division of Infectious Diseases, University of Iowa, Carver College of Medicine, IA, USA.
³⁶ Department of Microbiology, The University of Texas Health Science Center at Tyler, Tyler, TX, USA.
³⁷ Division of Infectious Diseases, Departments of Medicine and Cardiovascular Diseases, Mayo Clinic, College of Medicine and Science, Rochester, MN, USA.
³⁸ Infectious Diseases Service at the Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain.
³⁹ Department of Infectious Diseases and Tropical Medicine, University Medical Center of Nancy, Vandoeuvre Cedex, France. Electronic address: bruno@hoen.pro.
⁴⁰ Infectious Diseases Department at Barwon Health, University of Melbourne and Deakin University, Australia.
⁴¹ Geffen School of Medicine at UCLA Senior Investigator - LA Biomedical Research Institute at Harbor-UCLA, USA.
⁴² Department for Infectious Diseases, School of Medicine, University of Zagreb, Croatia.
⁴³ Duke University Medical Center, Hubert-Yeargan Center for Global Health, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
⁴⁴ Division of Infectious Diseases, Duke University Medical Center, Durham, NC, USA.
⁴⁵ Division of Infectious Diseases, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
⁴⁶ Departments of Medicine and Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC, USA.
⁴⁷ Department of Infectious Diseases and Tropical Medicine, University Medical Center of Nancy, Vandoeuvre Cedex, France.
⁴⁸ Harvard Medical School, Division of Infectious Diseases at the Beth Israel Deaconess Medical Center, Boston, MA, USA.
⁴⁹ Infectious and Transplant Medicine of the 'V. Monaldi' Teaching Hospital in Naples, University of Campania 'L. Vanvitelli', Italy.
⁵⁰ Infectious Diseases at the Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain.
⁵¹ Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic, College of Medicine and Science, Rochester, MN, USA.
⁵² Division of Infectious Diseases, Departments of Medicine and Cardiovascular Medicine, Mayo Clinic, College of Medicine and Science, Rochester, MN, USA.
⁵³ Division of Infectious Diseases, University of Iowa, Carver College of Medicine, Iowa, USA.
⁵⁴ Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona Spain.
⁵⁵ Infectious and Tropical Diseases Department, San Bortolo Hospital, Vincenza, Italy.
⁵⁶ Kaiser Permanente Infectious Diseases, LA, USA.
⁵⁷ Liverpool School of Tropical Medicine, Liverpool, UK.
⁵⁸ Department of Internal Medicine II, Division of Infectious Diseases, Medical Center, University of Freiburg, Freiburg i.Br, Germany.
⁵⁹ Division of Infectious Diseases, Department of Medicine, Queen Elizabeth Hospital, The University of Hong Kong, China.
⁶⁰ Infectious Disease, University of Iowa, USA.
⁶¹ Department of Infectious Diseases, Bern University Hospital, Bern, Switzerland.
⁶² Department of Infectious Diseases Monash University, Australia.
⁶³ Division of Infectious Diseases and Hospital Epidemiology, University Hospital and University of Basel, Switzerland.
⁶⁴ Department of Medical Microbiology, Radboud University Medical Centre, the Netherlands.
⁶⁵ Institute of Medical Microbiology, University of Zurich, Switzerland and Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
⁶⁶ Molecular and Experimental Mycobacteriology Group, Reserch Center, Borstel Germany.
⁶⁷ Diagnostic Mycobacteriology Group, National and WHO Supranational Reference Center for Mycobacteria, Research Center, Borstel Germany.
⁶⁸ Molecular and Experimental Mycobacteriology Group, Research Center, Borstel Germany and German Center for Infection Research (DZIF), partner site Hamburg - Lübeck - Borstel - Riems, Borstel, Germany.
⁶⁹ Heart Center, Charité Berlin, Germany.
⁷⁰ Clinic for Cardiovascular Surgery, University Hospital of Zurich, Switzerland.
⁷¹ Opthalmology Unit, University of Zurich, Switzerland.
⁷² Institute of Anaesthesiology, University Hospital Zurich, Switzerland.
⁷³ Department of Anaesthesiology, Kaiser Permanente, Los Angeles Medical Center, LA, USA.
⁷⁴ National Infection Service, Public Health England, Guy's and St Thomas' NHS Foundation Trust, Imperial College London, London, England, UK.
⁷⁵ European Centre for Disease Prevention and Control (ECDC), Solna, Sweden.
⁷⁶ Centers for Disease Control and Prevention, Atlanta, GA, USA.

PMID: 31715282
DOI: 10.1016/j.jhin.2019.10.009

Abstract

Mycobacterial infection-related morbidity and mortality in patients following cardiopulmonary bypass surgery is high and there is a growing need for a consensus-based expert opinion to provide international guidance for diagnosing, preventing and treating in these patients. In this document the International Society for Cardiovascular Infectious Diseases (ISCVID) covers aspects of prevention (field of hospital epidemiology), clinical management (infectious disease specialists, cardiac surgeons, ophthalmologists, others), laboratory diagnostics (microbiologists, molecular diagnostics), device management (perfusionists, cardiac surgeons) and public health aspects.

Keywords: Cardiopulmonary bypass; Disseminated; Guidelines; Heater-cooler device; ISCVID; Infection; Mycobacterial; Mycobacterium chimaera; Outbreaks.

Publication types

Practice Guideline

MeSH terms

Anti-Bacterial Agents / therapeutic use
Cardiac Surgical Procedures / adverse effects
Cardiac Surgical Procedures / methods
Cardiology
Cardiopulmonary Bypass
Communicable Diseases
Cross Infection* / diagnosis
Cross Infection* / drug therapy
Cross Infection* / microbiology
Cross Infection* / prevention & control
Equipment Contamination
Humans
Mycobacterium Infections, Nontuberculous* / diagnosis
Mycobacterium Infections, Nontuberculous* / drug therapy
Mycobacterium Infections, Nontuberculous* / prevention & control
Mycobacterium* / isolation & purification
Risk Factors
Societies, Medical
United Kingdom

Substances

Anti-Bacterial Agents

Supplementary concepts

Mycobacterium chimaera