Spectroscopic Properties of some Hydroxylated 2-Stilbazole Derivatives

J Fluoresc. 2019 Nov;29(6):1301-1309. doi: 10.1007/s10895-019-02445-6. Epub 2019 Nov 12.

Abstract

The spectroscopic properties for a number of new hydroxylated 2-stilbazoles were studied by absorption and fluorescence spectroscopy. The maximum absorption and emission wavelengths, the molar extinction coefficients, and the Stokes shift values of derivatives were given. The dependence of the spectral characteristics on pH was shown. The possibility of creating molecular logic systems and fluorescent dyes for bioimaging based on these derivatives was demonstrated. The dependence of fluorescence on the medium redox properties was established for an one of derivatives. The possibility of a fluorescent probe creating on its basis to assess the oxidative state of living systems was demonstrated. The probe has good biocompatibility and can be successfully used for fluorescence imaging in cells.

Keywords: 2-Stilbazoles; Cell imaging; Fluorescent probe; Logic gate; Photophysical properties.

MeSH terms

  • Animals
  • Cells, Cultured
  • Fluorescent Dyes / chemistry*
  • Hydrazines / chemistry*
  • Hydrogen-Ion Concentration
  • Mice
  • Molecular Structure
  • Optical Imaging
  • Pyridines / chemistry*
  • Spectrometry, Fluorescence

Substances

  • 4'-hydrazino-2-stilbazole
  • Fluorescent Dyes
  • Hydrazines
  • Pyridines