Optic perineuritis with anti-myelin oligodendrocyte glycoprotein antibody

Mult Scler Relat Disord. 2020 Feb:38:101444. doi: 10.1016/j.msard.2019.101444. Epub 2019 Oct 14.

Abstract

A 25-year-old male presented with blurred peripheral vision and movement pain in his right eye. Fundus examination revealed unilateral disc swelling in his right eye with normal intracranial pressure. MRI showed remarkably high intensity in the optic nerve sheath and slightly high intensity in the optic nerve, indicating optic perineuritis (OPN). Anti-myelin oligodendrocyte glycoprotein (MOG) antibody was positive in both serum and cerebrospinal fluid. The patient responded promptly to corticosteroid treatment. OPN can be associated with the presence of anti-MOG antibody.

Keywords: Disc swelling; MOG; Myelin oligodendrocyte glycoprotein; Optic perineuritis.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage
  • Adrenal Cortex Hormones / pharmacology*
  • Adult
  • Autoantibodies / blood
  • Autoantibodies / cerebrospinal fluid
  • Autoantibodies / metabolism*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Myelin-Oligodendrocyte Glycoprotein / immunology*
  • Optic Neuritis / complications
  • Optic Neuritis / diagnosis*
  • Optic Neuritis / drug therapy
  • Optic Neuritis / immunology
  • Papilledema / diagnostic imaging
  • Papilledema / drug therapy
  • Papilledema / etiology
  • Prednisolone / pharmacology
  • Vision Disorders* / etiology

Substances

  • Adrenal Cortex Hormones
  • Autoantibodies
  • MOG protein, human
  • Myelin-Oligodendrocyte Glycoprotein
  • Prednisolone