Clinical Practice Patterns in Temporary Mechanical Circulatory Support for Shock in the Critical Care Cardiology Trials Network (CCCTN) Registry

Circ Heart Fail. 2019 Nov;12(11):e006635. doi: 10.1161/CIRCHEARTFAILURE.119.006635. Epub 2019 Nov 11.

Abstract

Background: Temporary mechanical circulatory support (MCS) devices provide hemodynamic assistance for shock refractory to pharmacological treatment. Most registries have focused on single devices or specific etiologies of shock, limiting data regarding overall practice patterns with temporary MCS in cardiac intensive care units.

Methods: The CCCTN (Critical Care Cardiology Trials Network) is a multicenter network of tertiary CICUs in North America. Between September 2017 and September 2018, each center (n=16) contributed a 2-month snapshot of consecutive medical CICU admissions.

Results: Of the 270 admissions using temporary MCS, 33% had acute myocardial infarction-related cardiogenic shock (CS), 31% had CS not related to acute myocardial infarction, 11% had mixed shock, and 22% had an indication other than shock. Among all 585 admissions with CS or mixed shock, 34% used temporary MCS during the CICU stay with substantial variation between centers (range: 17%-50%). The most common temporary MCS devices were intraaortic balloon pumps (72%), Impella (17%), and veno-arterial extracorporeal membrane oxygenation (11%), although intraaortic balloon pump use also varied between centers (range: 40%-100%). Patients managed with intraaortic balloon pump versus other forms of MCS (advanced MCS) had lower Sequential Organ Failure Assessment scores and less severe metabolic derangements. Illness severity was similar at high- versus low-MCS utilizing centers and at centers with more advanced MCS use.

Conclusions: There is wide variation in the use of temporary MCS among patients with shock in tertiary CICUs. While hospital-level variation in temporary MCS device selection is not explained by differences in illness severity, patient-level variation appears to be related, at least in part, to illness severity.

Keywords: critical care; extracorporeal membrane oxygenation; hemodynamics; myocardial infarction; shock.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Cardiologists / trends*
  • Coronary Care Units / trends*
  • Extracorporeal Membrane Oxygenation / adverse effects
  • Extracorporeal Membrane Oxygenation / instrumentation
  • Extracorporeal Membrane Oxygenation / mortality
  • Extracorporeal Membrane Oxygenation / trends*
  • Female
  • Healthcare Disparities / trends*
  • Heart-Assist Devices / trends*
  • Hemodynamics*
  • Humans
  • Intra-Aortic Balloon Pumping / adverse effects
  • Intra-Aortic Balloon Pumping / instrumentation
  • Intra-Aortic Balloon Pumping / mortality
  • Intra-Aortic Balloon Pumping / trends*
  • Male
  • Middle Aged
  • North America / epidemiology
  • Patient Admission / trends
  • Practice Patterns, Physicians' / trends*
  • Recovery of Function
  • Risk Factors
  • Severity of Illness Index
  • Shock, Cardiogenic / diagnosis
  • Shock, Cardiogenic / mortality
  • Shock, Cardiogenic / physiopathology
  • Shock, Cardiogenic / therapy*
  • Time Factors
  • Treatment Outcome