Impaired Muscle Regeneration in Cancer-Associated Cachexia

Trends Cancer. 2019 Oct;5(10):579-582. doi: 10.1016/j.trecan.2019.07.010. Epub 2019 Aug 16.

Abstract

Muscle wasting, a cardinal feature of cancer-associated cachexia (CAC), is a major clinical problem with few therapeutic options. In this Forum article we discuss cellular mechanisms of CAC, focusing on impaired muscle regeneration. We highlight muscle progenitor cell dysfunction and metabolism as two variables contributing to impaired regeneration in CAC.

Keywords: cachexia; muscle wasting; regeneration; satellite cells.

Publication types

  • Review

MeSH terms

  • Cachexia / etiology*
  • Cachexia / pathology*
  • Cachexia / physiopathology
  • Cell Differentiation
  • Cell Proliferation
  • Energy Metabolism
  • Humans
  • Muscle, Skeletal / metabolism*
  • Muscle, Skeletal / pathology*
  • Muscle, Skeletal / physiopathology
  • Muscular Atrophy / etiology
  • Muscular Atrophy / metabolism
  • Muscular Atrophy / pathology
  • Muscular Atrophy / physiopathology
  • Myoblasts / cytology
  • Myoblasts / metabolism
  • Neoplasms / complications*
  • Regeneration
  • Satellite Cells, Skeletal Muscle / cytology
  • Satellite Cells, Skeletal Muscle / metabolism