Abstract
Muscle wasting, a cardinal feature of cancer-associated cachexia (CAC), is a major clinical problem with few therapeutic options. In this Forum article we discuss cellular mechanisms of CAC, focusing on impaired muscle regeneration. We highlight muscle progenitor cell dysfunction and metabolism as two variables contributing to impaired regeneration in CAC.
Keywords:
cachexia; muscle wasting; regeneration; satellite cells.
Copyright © 2019 Elsevier Inc. All rights reserved.
MeSH terms
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Cachexia / etiology*
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Cachexia / pathology*
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Cachexia / physiopathology
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Cell Differentiation
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Cell Proliferation
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Energy Metabolism
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Humans
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Muscle, Skeletal / metabolism*
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Muscle, Skeletal / pathology*
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Muscle, Skeletal / physiopathology
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Muscular Atrophy / etiology
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Muscular Atrophy / metabolism
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Muscular Atrophy / pathology
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Muscular Atrophy / physiopathology
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Myoblasts / cytology
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Myoblasts / metabolism
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Neoplasms / complications*
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Regeneration
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Satellite Cells, Skeletal Muscle / cytology
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Satellite Cells, Skeletal Muscle / metabolism