Functional evaluation of isocitrate dehydrogenase 1 and 2 variants of unclear significance in chronic myeloid neoplasms

Leuk Res. 2019 Dec:87:106264. doi: 10.1016/j.leukres.2019.106264. Epub 2019 Oct 24.

Affiliations

¹ Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
² Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
³ Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address: lasho.terra@mayo.edu.

PMID: 31706195
DOI: 10.1016/j.leukres.2019.106264

No abstract available

Publication types

Letter

MeSH terms

Adult
Aged
Aged, 80 and over
Bone Marrow Neoplasms / epidemiology
Bone Marrow Neoplasms / genetics*
Case-Control Studies
DNA Mutational Analysis
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Isocitrate Dehydrogenase / genetics*
Male
Middle Aged
Mutation* / physiology
Myelodysplastic Syndromes / epidemiology
Myelodysplastic Syndromes / genetics*
Myeloproliferative Disorders / epidemiology
Myeloproliferative Disorders / genetics*
Survival Analysis

Substances

IDH2 protein, human
Isocitrate Dehydrogenase
IDH1 protein, human