Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica

Abilova Zhamilya; Jie Yuan; Jenis Janar; Chun-Ping Tang; Yang Ye

doi:10.1016/S1875-5364(19)30095-0

Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica

Chin J Nat Med. 2019 Oct;17(10):785-791. doi: 10.1016/S1875-5364(19)30095-0.

Authors

Abilova Zhamilya¹, Jie Yuan¹, Jenis Janar², Chun-Ping Tang³, Yang Ye⁴

Affiliations

¹ University of Chinese Academy of Sciences, Beijing 100049, China; State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
² State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Research Center for Medicinal Plants, Al-Farabi Kazakh National University, Al-Farabi ave. 71, 050040 Almaty, Republic of Kazakhstan.
³ State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
⁴ State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address: yye@shcnc.ac.cn.

PMID: 31703759
DOI: 10.1016/S1875-5364(19)30095-0

Abstract

One new dimeric (1) and two monomeric sesquiterpene lactones (5 and 13), together with 10 known compounds (2-4, 6-12), were isolated from Artemisia heptapotamica collected in Almaty region of Kazakhstan. All compounds were isolated from this plant for the first time. The structures of the new compounds were mainly achieved by extensive analysis of MS, 1D and 2D NMR spectroscopic data, and ECD spectrum as well. The inhibitory activities of all isolates against activation of NF-κB induced by LPS were assessed on a THP1-Dual cell model. Some of them showed strong inhibitory activity with IC₅₀ values ranging from 2 to 25 μmol·L^-1.

Keywords: Ajaniaolide B; Anti-inflammation; Artemdubolide I; Artemisia heptapotamica; Artemisiane E; Sesquiterpene lactone.

MeSH terms

Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / pharmacology
Artemisia / chemistry*
Cell Line
Dimerization
Humans
Lactones / chemistry*
Lactones / pharmacology
Magnetic Resonance Spectroscopy
Molecular Structure
Monocytes / drug effects
Monocytes / immunology
NF-kappa B / genetics
NF-kappa B / immunology
Plant Extracts / chemistry*
Plant Extracts / pharmacology
Sesquiterpenes / chemistry*
Sesquiterpenes / pharmacology

Substances

Anti-Inflammatory Agents
Lactones
NF-kappa B
Plant Extracts
Sesquiterpenes