The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities

Hyeyoun Chang; Zhenying Cai; Thomas M Roberts

doi:10.3390/biom9110713

The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities

Biomolecules. 2019 Nov 7;9(11):713. doi: 10.3390/biom9110713.

Authors

Hyeyoun Chang^{1

2

3}, Zhenying Cai^{1

2}, Thomas M Roberts^{1

2}

Affiliations

¹ Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
² Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA.
³ KIST-DFCI On-Site Lab, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Abstract

In this review, we will first briefly describe the diverse molecular mechanisms associated with PTEN loss of function in cancer. We will then proceed to discuss the molecular mechanisms linking PTEN loss to PI3K activation and demonstrate how these mechanisms suggest possible therapeutic approaches for patients with PTEN-null tumors.

Keywords: PI3K; PTEN; cancer.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Molecular Targeted Therapy*
Mutation / genetics
Neoplasms / genetics*
Neoplasms / pathology
PTEN Phosphohydrolase / genetics*
Phosphatidylinositol 3-Kinases / genetics
Proto-Oncogene Proteins c-akt / genetics
Signal Transduction / genetics

Substances

Proto-Oncogene Proteins c-akt
PTEN Phosphohydrolase
PTEN protein, human

Abstract

Publication types

MeSH terms

Substances

Grants and funding