JMJD3 in the regulation of human diseases

Protein Cell. 2019 Dec;10(12):864-882. doi: 10.1007/s13238-019-0653-9. Epub 2019 Nov 7.

Abstract

In recent years, many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases. The Jumonji domain-containing protein D3 (JMJD3), specifically demethylate di- and trimethyl-lysine 27 on histone H3 (H3K27me2/3), has been widely studied in immune diseases, infectious diseases, cancer, developmental diseases, and aging related diseases. We will focus on the recent advances of JMJD3 function in human diseases, and looks ahead to the future of JMJD3 gene research in this review.

Keywords: JMJD3; epigenetics; histone methylation; human diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / metabolism*
  • Animals
  • Cell Line
  • Communicable Diseases / metabolism*
  • Embryonic Development
  • Humans
  • Immune System Diseases / metabolism*
  • Jumonji Domain-Containing Histone Demethylases / physiology*
  • Neoplasms / metabolism*

Substances

  • Jumonji Domain-Containing Histone Demethylases
  • KDM6B protein, human