Regulation of Cell Behavior by Hydrostatic Pressure

Shaobao Liu; Ru Tao; Ming Wang; Jin Tian; Guy M Genin; Tian Jian Lu; Feng Xu

doi:10.1115/1.4043947

Regulation of Cell Behavior by Hydrostatic Pressure

Appl Mech Rev. 2019 Jul;71(4):0408031-4080313. doi: 10.1115/1.4043947. Epub 2019 Jul 23.

Authors

Shaobao Liu¹, Ru Tao², Ming Wang², Jin Tian³, Guy M Genin⁴, Tian Jian Lu¹, Feng Xu²

Affiliations

¹ State Key Laboratory of Mechanics andControl of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China.
² The Key Laboratory of Biomedical InformationEngineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
³ Department of Biomedical Engineering,Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, China.
⁴ The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.

Abstract

Hydrostatic pressure (HP) regulates diverse cell behaviors including differentiation, migration, apoptosis, and proliferation. Abnormal HP is associated with pathologies including glaucoma and hypertensive fibrotic remodeling. In this review, recent advances in quantifying and predicting how cells respond to HP across several tissue systems are presented, including tissues of the brain, eye, vasculature and bladder, as well as articular cartilage. Finally, some promising directions on the study of cell behaviors regulated by HP are proposed.

Keywords: cell micro-environment; cell volume; mechanobiology; mechanotransduction.

Publication types

Review