TCR Ligand Discovery via T-Scan

Zhe Wang; Genhong Cheng; Guideng Li

doi:10.1016/j.it.2019.10.003

TCR Ligand Discovery via T-Scan

Trends Immunol. 2019 Dec;40(12):1075-1077. doi: 10.1016/j.it.2019.10.003. Epub 2019 Nov 5.

Authors

Zhe Wang¹, Genhong Cheng², Guideng Li³

Affiliations

¹ Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou 215123, China.
² Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: gcheng@mednet.ucla.edu.
³ Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou 215123, China. Electronic address: lgd@ism.cams.cn.

PMID: 31699586
DOI: 10.1016/j.it.2019.10.003

Abstract

T cell receptor (TCR) ligand discovery is crucial to monitoring T cell responses to antigen and to identifying antigens reactive against orphan TCRs of interest. In a recent article, Elledge and colleagues describe a functional T cell ligand screening platform for unbiased TCR ligand discovery.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Epitopes, T-Lymphocyte*
Ligands
Receptors, Antigen, T-Cell*
T-Lymphocytes / immunology

Substances

Epitopes, T-Lymphocyte
Ligands
Receptors, Antigen, T-Cell