Polyprenylated xanthones from the twigs and leaves of Garcinia nujiangensis and their cytotoxic evaluation

Bioorg Chem. 2020 Jan:94:103370. doi: 10.1016/j.bioorg.2019.103370. Epub 2019 Oct 24.

Abstract

Inspired by the intriguing structures and bioactivities of polyprenylated xanthones, ten previously undescribed polyprenylated xanthones, nujiangxanthones G-P (1-10), and fifteen known ones (11-25) were isolated from the twigs and leaves of Garcinia nujiangensis. The structures of these compounds were established on the basis of spectroscopic data as well as comparison with the literature. Most of the isolates showed potent cytotoxicity against selected cancer cells. Compound 8 showed the highest effects against MDA-MB-231 and A549 cell lines with IC50 values of 4.12 and 2.67 μM and 16 demonstrated the most potent activity against MCF-7 cell line with an IC50 value of 3.36 μM.

Keywords: Cytotoxic activities; Garcinia nujiangensis; Polyprenylated xanthones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Garcinia / chemistry*
  • Humans
  • Molecular Structure
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Structure-Activity Relationship
  • Xanthones / chemistry
  • Xanthones / isolation & purification
  • Xanthones / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Xanthones