Mitochondrial Translation Initiation Factor 3: Structure, Functions, Interactions, and Implication in Human Health and Disease

I V Chicherin; M V Baleva; S A Levitskii; E B Dashinimaev; I A Krasheninnikov

doi:10.1134/S0006297919100031

Mitochondrial Translation Initiation Factor 3: Structure, Functions, Interactions, and Implication in Human Health and Disease

Biochemistry (Mosc). 2019 Oct;84(10):1143-1150. doi: 10.1134/S0006297919100031.

Authors

I V Chicherin^{1

2}, M V Baleva³, S A Levitskii³, E B Dashinimaev^{4

5}, I A Krasheninnikov³

Affiliations

¹ Lomonosov Moscow State University, Faculty of Biology, Moscow, 119234, Russia. i.v.chicherin@gmail.com.
² Institute of Functional Genomics, Lomonosov Moscow State University, Moscow, 119234, Russia.
³ Lomonosov Moscow State University, Faculty of Biology, Moscow, 119234, Russia.
⁴ Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334, Russia. dashinimaev@gmail.com.
⁵ Pirogov Russian National Research Medical University, Moscow, 117977, Russia.

PMID: 31694510
DOI: 10.1134/S0006297919100031

Abstract

Mitochondria are essential organelles of eukaryotic cell that provide its respiratory function by means of the electron transfer chain. Expression of mitochondrial genes is organized in a bacterial-like manner; however multiple evolutionary differences are observed between the two systems, including translation initiation machinery. This review is dedicated to the mitochondrial translation initiation factor 3 (IF3mt), which plays a key role in the protein synthesis in mitochondria. Involvement of IF3mt in human health and disease is discussed.

Publication types

Review

MeSH terms

Eukaryotic Initiation Factors / chemistry*
Eukaryotic Initiation Factors / metabolism*
Humans
Mitochondria / metabolism
Mitochondrial Proteins / chemistry*
Mitochondrial Proteins / metabolism*
Parkinson Disease / metabolism*

Substances

Eukaryotic Initiation Factors
MTIF3 protein, human
Mitochondrial Proteins