The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease

Tatiana Kisseleva; David A Brenner

doi:10.1016/j.cmet.2019.10.010

The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease

Cell Metab. 2019 Nov 5;30(5):850-852. doi: 10.1016/j.cmet.2019.10.010.

Authors

Tatiana Kisseleva¹, David A Brenner²

Affiliations

¹ Department of Surgery, University of California, San Diego, San Diego, CA 92093, USA. Electronic address: tkisseleva@ucsd.edu.
² Department of Medicine, University of California, San Diego, San Diego, CA 92093, USA. Electronic address: dbrenner@ucsd.edu.

PMID: 31693880
DOI: 10.1016/j.cmet.2019.10.010

Abstract

Choi et al. (2019) explored the pathogenesis of alcohol-induced de novo lipogenesis in mice with ALD to reveal a novel mechanism of cannabinoid 1 receptor (CB1R)-SREB1-dependent triglyceride synthesis that requires crosstalk between hepatocytes and HSCs. Using genetic and pharmacological inhibition of the key components of the xCT-glutamate→mGluR5-2-AG→CB₁R-SREBP1-FASN paracrine communication system, Choi et al. identified potential new targets for drugs for ALD.

Publication types

Comment

MeSH terms

Animals
Glutamates
Hepatic Stellate Cells*
Hepatocytes
Liver Diseases, Alcoholic*
Macrophages
Mice

Substances

Glutamates

Grants and funding

P50 AA011999/AA/NIAAA NIH HHS/United States