Telomere maintenance: regulating hTERC fate through RNA modifications

Lisa Lirussi; Hilde Nilsen

doi:10.1080/23723556.2019.1670489

Telomere maintenance: regulating hTERC fate through RNA modifications

Mol Cell Oncol. 2019 Oct 15;6(6):e1670489. doi: 10.1080/23723556.2019.1670489. eCollection 2019.

Authors

Lisa Lirussi^{1

2}, Hilde Nilsen^{1

2}

Affiliations

¹ Department of Clinical Molecular Biology, University of Oslo, Oslo, Norway.
² Department of Clinical Molecular Biology (EpiGen), Akershus University Hospital, Lørenskog, Norway.

Abstract

Disturbances in telomere maintenance are common in cancer. We recently showed that Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) promotes telomere homeostasis by regulating the stability of the telomeric RNA component (hTERC). SMUG1-mediated recognition of base modifications may function in a regulated process serving to fine-tune the levels of hTERC.

Keywords: Base Excision Repair; Cancer; RNA processing; SMUG1; Telomere; hTERC.

Grants and funding

This work was supported by the Research Council of Norway under Grant [number 229633] and by the Norwegian Cancer Society under Grant [number 4501723-2015].