One way to rule them all: G2/M gene regulation by oncogenic YAP1 and B-MYB

Grit Weinstock; Stefan Gaubatz

doi:10.1080/23723556.2019.1648026

One way to rule them all: G2/M gene regulation by oncogenic YAP1 and B-MYB

Mol Cell Oncol. 2019 Aug 9;6(6):e1648026. doi: 10.1080/23723556.2019.1648026. eCollection 2019.

Authors

Grit Weinstock¹, Stefan Gaubatz¹

Affiliation

¹ Theodor Boveri Institute and Comprehensive Cancer Center Mainfranken, Biocenter, University of Wuerzburg, Wuerzburg, Germany.

Abstract

The Hippo pathway plays a major role in regulating organ size during embryogenesis. Loss of Hippo signaling can cause cancer due to unrestricted cell proliferation. Recently we found that Yes-associated protein 1 (YAP1), the major downstream effector of Hippo, promotes mitotic gene expression and proliferation through binding and activating the Myb-MuvB (MMB) complex subunit MYB proto-oncogene like 2 (B-MYB).

Keywords: B-MYB; MuvB; YAP1; cell cycle; enhancer; gene expression.

Grants and funding

Our work is supported by grants from the Deutsche Krebshilfe (110928), the Wilhelm Sander-Stiftung (2015.038.2) and the Deutsche Forschungsgemeinschaft (DFG, GA575/9-1).