Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry

Baiba Svalbe; Solveiga Grinberga; Gundega Stelfa; Edijs Vavers; Baiba Zvejniece; Eduards Sevostjanovs; Maija Dambrova; Liga Zvejniece

doi:10.1016/j.dib.2019.104623

Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry

Data Brief. 2019 Oct 4:27:104623. doi: 10.1016/j.dib.2019.104623. eCollection 2019 Dec.

Authors

Baiba Svalbe¹, Solveiga Grinberga¹, Gundega Stelfa^{1

2}, Edijs Vavers^{1

3}, Baiba Zvejniece¹, Eduards Sevostjanovs¹, Maija Dambrova^{1

3}, Liga Zvejniece¹

Affiliations

¹ Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, LV-1006, Latvia.
² Latvia University of Life Sciences and Technologies, K.Helmana 8, Jelgava, LV-3004, Latvia.
³ Riga Stradins University, Dzirciema 16, Riga, LV-1007, Latvia.

Abstract

MK-801, a N-methyl-d-aspartate receptor antagonist, is widely used in animal preclinical experiments to induce memory and learning impairments and schizophrenia-like behavior. In the present study, we compared the plasma and brain tissue concentrations of MK-801 after intraperitoneal (i.p.) or subcutaneous (s.c.) administration at a dose of 0.1 mg/kg in male ICR mice. Moreover, these data present the optimization of ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the analysis of MK-801 in biological samples. Procedures for the preparation of brain tissue and plasma samples and instrumental analysis are described. This article is related to a research article entitled "Effects of the N-methyl-d-aspartate receptor antagonist, MK-801, on spatial memory and influence of the route of administration" [1].

Keywords: Bioavailability; MK-801; Mice; UPLC-MS/MS; i.p. and s.c. administration route.