Mineralized Supramolecular Hydrogels Bearing Tunable Thermo-Responsiveness

Abstract

Although a variety of biomimetic mineralized materials have been created in the lab, the vast majority of these manmade examples lack response to external stimuli. Here, mineralized supramolecular hydrogels with on-demand thermo-responsiveness that are formed by a simple, physical crosslinking between amorphous CaCO₃ (ACC) nanoparticles and poly(acrylic acid) (PAA) are reported. Upon the addition of Na₂ CO₃ solution into a mixture composed of PAA and CaCl₂ , amorphous ACC nanoparticles are formed in situ and simultaneously crosslinked by PAA chains, giving rise to the mineralized hydrogels. Interestingly, upon tuning the content of the formed ACC, hydrogels with different types of thermo-responsiveness can be easily obtained, and the transparencies of the resulting hydrogels are dramatically changed during the temperature-driven phase transitions. As an application, these thermo-responsive mineralized hydrogels are used to control the exposure of UV light, which is successfully applied to switch fluorescent signals in response to temperature.

Keywords: amorphous calcium carbonate; hydrogels; mineralization; supramolecular chemistry; thermo-responsiveness.