Oligodendroglioma with Neuronal Differentiation in Two Boxer Dogs

J Comp Pathol. 2019 Oct:172:11-16. doi: 10.1016/j.jcpa.2019.08.003. Epub 2019 Sep 18.

Abstract

Two cases of high-grade glioma comprising sheets of oligodendroglial cells multifocally disrupted by regions of remarkable neuronal differentiation are described. These tumours morphologically resemble 'oligodendroglioma with ganglioglioma-like maturation', a rare tumour of man, but appear to be phenotypically more aggressive. Neuronal markers (synaptophysin, neuron-specific enolase and βIII-tubulin) effectively highlight neuronal elements within these tumours and could potentially help to further investigate the prevalence and biological significance of neuronal differentiation in canine oligodendroglioma.

Keywords: dog; glioma; neuronal differentiation; oligodendroglioma.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Brain Neoplasms / metabolism
  • Brain Neoplasms / pathology
  • Brain Neoplasms / veterinary*
  • Cell Differentiation
  • Dog Diseases / metabolism
  • Dog Diseases / pathology*
  • Dogs
  • Histocytochemistry
  • Male
  • Neurons / metabolism
  • Neurons / pathology
  • Oligodendroglia / metabolism
  • Oligodendroglia / pathology
  • Oligodendroglioma / metabolism
  • Oligodendroglioma / pathology
  • Oligodendroglioma / veterinary*
  • Phosphopyruvate Hydratase / metabolism*
  • Synaptophysin / metabolism*
  • Tubulin / metabolism*

Substances

  • Biomarkers
  • Synaptophysin
  • Tubulin
  • Phosphopyruvate Hydratase