C-type lectin receptor-mediated immune recognition and response of the microbiota in the gut

Tian-Hang Li; Ling Liu; Ya-Yi Hou; Su-Nan Shen; Ting-Ting Wang

doi:10.1093/gastro/goz028

C-type lectin receptor-mediated immune recognition and response of the microbiota in the gut

Gastroenterol Rep (Oxf). 2019 Jul 10;7(5):312-321. doi: 10.1093/gastro/goz028. eCollection 2019 Oct.

Authors

Tian-Hang Li¹, Ling Liu¹, Ya-Yi Hou^{1

2}, Su-Nan Shen^{1

2}, Ting-Ting Wang^{1

2}

Affiliations

¹ Immunology and Reproduction Biology Lab, Medical School of Nanjing University, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu, P. R. China.
² Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, Jiangsu, P. R. China.

Abstract

C-type lectin receptors (CLRs) are powerful pattern-recognition receptors that discern 'self' and 'non-self' in our body and protect us from invasive pathogens by mediating immune recognition and response. The gastrointestinal tract is very important for the maintenance of homeostasis; it is the largest shelter for the billions of microorganisms in the body and CLRs play a crucial regulatory role in this system. This study focuses on several CLRs, including Dectin-1, Dectin-2, Dectin-3 and Mincle. We summarize the roles of CLRs in maintaining gastrointestinal immune-system homeostasis, especially their functions in mediating immune recognition and responses in the gut, discuss their relationships to some diseases, highlight the significance of CLR-mediated sensing of microbial and non-microbial compounds in the gut immune system and identify new therapeutic targets.

Keywords: C-type lectin receptors (CLRs); immunity; inflammatory bowel disease (IBD); microbiota.

Publication types

Review