Lipoprotein(a) as a marker for predicting coronary collateral circulation in patients with acute myocardial infarction

Per Med. 2020 Jan;17(1):67-78. doi: 10.2217/pme-2018-0127. Epub 2019 Nov 5.

Abstract

Aim: The aim of the present study was to examine the predictive value of lipoprotein(a) (Lp[a]) levels for coronary collateral circulation (CCC) in patients with acute myocardial infarction (AMI). Method & methods: A total of 409 consecutive patients with AMI were enrolled for this study. Patients were divided into two groups according to rentrop grades assessed by coronary angiography: bad (n = 277) and good CCC group (n = 132). Result: Patients with bad CCC had a higher level of Lp(a) than that with good CCC (median Lp[a] 219.1 vs 122.0 mg/l). The area under the receiver-operating characteristic curves of Lp(a) in predicting bad CCC was 0.647 (95% CI: 0.592-0.702) with the cut-off value of 199.0 mg/l. Conclusion: Our data firstly suggested that Lp(a) might be a useful marker for CCC after AMI.

Keywords: Lipoprotein(a); acute myocardial infarction; collateral circulation; coronary artery; marker; prediction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Area Under Curve
  • Biomarkers / metabolism*
  • Collateral Circulation*
  • Coronary Angiography
  • Cross-Sectional Studies
  • Female
  • Humans
  • Lipoprotein(a) / metabolism*
  • Male
  • Middle Aged
  • Myocardial Infarction / diagnostic imaging*
  • Myocardial Infarction / metabolism

Substances

  • Biomarkers
  • LPA protein, human
  • Lipoprotein(a)