We propose a multilayer slab waveguide (SWG) to enhance the resonance of the transmittance with a guided-mode resonance (GMR) filter. The resonance characteristics of the GMR filter were studied in three types according to the method of attaching the grating film to a SWG, which consists of 25 µm thick polyethylene terephthalate (PET) film layers separated by 25 µm air layers. The resonance depth with the multilayer SWG was improved over that of the monolayer SWG because the refractive index and absorption of the multilayer SWG were reduced. However, because resonance with a high Q-factor in the monolayer SWG has a large attenuation loss due to material absorption, the resonance enhancement was insufficient even for the multilayer SWG. We were able to make the resonance depth up to 5.2 times larger than the monolayer SWG in the TE1,1 mode using a five-layer SWG. We verified the enhancements with the multilayer SWG using a finite-difference frequency-domain (FDFD) simulation.