Targeting miRNAs by polyphenols: Novel therapeutic strategy for aging

Maryam Majidinia; Ansar Karimian; Forough Alemi; Bahman Yousefi; Amin Safa

doi:10.1016/j.bcp.2019.113688

Targeting miRNAs by polyphenols: Novel therapeutic strategy for aging

Biochem Pharmacol. 2020 Mar:173:113688. doi: 10.1016/j.bcp.2019.113688. Epub 2019 Nov 1.

Authors

Maryam Majidinia¹, Ansar Karimian², Forough Alemi³, Bahman Yousefi⁴, Amin Safa⁵

Affiliations

¹ Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran.
² Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Student Research Committee, Babol University of medical sciences, Babol, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
³ Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
⁴ Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: yousefib@tbzmed.ac.ir.
⁵ Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam. Electronic address: aminsafa@duytan.edu.vn.

PMID: 31682793
DOI: 10.1016/j.bcp.2019.113688

Abstract

Regarding the importance of genetic and epigenetic factors in regulation of aging process, different expression pattern of non-coding RNAs in aging could be investigated. Accordingly, micro RNAs (miRNAs) with a wide range of physiological functions as well as a significant footprint in many diseases have been demonstrated to be down or upregulated during the aging process. Therefore, age-associated microRNAs and their targets have potentially detected the accelerated aging and predicted the risks for age-related diseases. Polyphenols as important antioxidants in human dietary observed in fruits and some beverages have beneficial effects on longevity and aging. Considering miRNAs as an interesting mediator in modulating polyphenols' biological effects, targeting miRNAs which is using polyphenols could be a novel strategy for aging.

Keywords: Aging; Polyphenols; miRNA.

Publication types

Review

MeSH terms

Aging / genetics*
Cardiovascular Diseases / genetics
Catechin / analogs & derivatives
Catechin / therapeutic use
Gene Expression Regulation / drug effects*
Humans
Longevity / genetics*
MicroRNAs / genetics*
Neoplasms / genetics
Nervous System Diseases / genetics
Polyphenols / metabolism
Polyphenols / therapeutic use*

Substances

MicroRNAs
Polyphenols
Catechin
epigallocatechin gallate