Nano/Micromotors for Diagnosis and Therapy of Cancer and Infectious Diseases

Chemistry. 2020 Feb 21;26(11):2309-2326. doi: 10.1002/chem.201903475. Epub 2019 Dec 20.

Abstract

Micromotors are man-made nano/microscale devices capable of transforming energy into mechanical motion. The accessibility and force offered by micromotors hold great promise to solve complex biomedical challenges. This Review highlights current progress and prospects in the use of nano and micromotors for diagnosis and treatment of infectious diseases and cancer. Motion-based sensing and fluorescence switching detection strategies along with therapeutic approaches based on direct cell capture; killing by direct contact or specific drug delivery to the affected site, will be comprehensively covered. Future challenges to translate the potential of nano/micromotors into practical applications will be described in the conclusions.

Keywords: bacteria; cancer cell; killing; micromotor; therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents / chemistry*
  • Antineoplastic Agents / chemistry*
  • Biosensing Techniques
  • Communicable Diseases / diagnosis*
  • Communicable Diseases / therapy*
  • Drug Delivery Systems
  • Humans
  • Microtechnology / methods
  • Nanostructures / chemistry*
  • Nanotechnology / methods
  • Neoplasms / diagnosis*
  • Neoplasms / therapy*

Substances

  • Anti-Infective Agents
  • Antineoplastic Agents