Effects of Fetal Substance Exposure on Offspring Substance Use

Neil C Dodge; Joseph L Jacobson; Sandra W Jacobson

doi:10.1016/j.pcl.2019.08.010

Effects of Fetal Substance Exposure on Offspring Substance Use

Pediatr Clin North Am. 2019 Dec;66(6):1149-1161. doi: 10.1016/j.pcl.2019.08.010.

Authors

Neil C Dodge¹, Joseph L Jacobson², Sandra W Jacobson²

Affiliations

¹ Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Drive, Suite 1-B, Detroit, MI 48201, USA. Electronic address: neildodge@wayne.edu.
² Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Drive, Suite 1-B, Detroit, MI 48201, USA.

Abstract

Prenatal exposure to alcohol and drugs is associated with physical, cognitive, and behavioral problems across the offspring's lifespan and an increased risk of alcohol and drug use in adolescent and young adult offspring. These prenatal effects continue to be evident after control for demographic background and parental alcohol and drug use. Behavior problems in childhood and adolescence associated with prenatal exposures may serve as a mediator of the prenatal exposure effects on offspring substance use.

Keywords: Adolescent alcohol; Adolescent substance use disorders; Cigarettes; Cocaine; Marijuana; Prenatal alcohol and drug exposure; Prenatal alcohol exposure; Substance abuse risk.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Adolescent
Adolescent Behavior
Female
Fetal Alcohol Spectrum Disorders / etiology
Humans
Maternal Behavior
Pregnancy
Prenatal Exposure Delayed Effects / etiology*
Risk Factors
Substance-Related Disorders / etiology*

Abstract

Publication types

MeSH terms

Grants and funding