US Immigration Is Associated With Rapid and Persistent Acquisition of Antibiotic Resistance Genes in the Gut

Quentin Le Bastard; Pajau Vangay; Eric Batard; Dan Knights; Emmanuel Montassier

doi:10.1093/cid/ciz1087

US Immigration Is Associated With Rapid and Persistent Acquisition of Antibiotic Resistance Genes in the Gut

Clin Infect Dis. 2020 Jul 11;71(2):419-421. doi: 10.1093/cid/ciz1087.

Authors

Quentin Le Bastard^{1

2}, Pajau Vangay³, Eric Batard^{1

2}, Dan Knights^{3

4

5}, Emmanuel Montassier^{1

2

6}

Affiliations

¹ MiHAR Laboratory, Université de Nantes, Nantes, France.
² Emergency Department, Nantes University Hospital, Nantes, France.
³ Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, Minnesota, USA.
⁴ Biotechnology Institute, University of Minnesota, Minneapolis, Minnesota, USA.
⁵ Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
⁶ EA3826 Thérapeutiques Anti-infectieuses, Institut de Recherche en Santé 2 Nantes Biotech, Medical University of Nantes, Nantes, France.

PMID: 31679002
DOI: 10.1093/cid/ciz1087

Abstract

Little is known about the effect of human migration on gut microbiome antibiotic resistance gene (ARG) carriage. Using deep shotgun stool metagenomics analysis, we found a rapid increase in gut microbiome ARG richness and abundance in women from 2 independent ethnic groups relocating from Thailand to the United States.

Keywords: antibiotic resistance genes; antimicrobial resistance; gut resistome; human migration.

MeSH terms

Anti-Bacterial Agents / pharmacology
Drug Resistance, Microbial
Emigration and Immigration*
Female
Gastrointestinal Microbiome* / genetics
Humans
Metagenomics
Thailand

Substances

Anti-Bacterial Agents