Advanced nanotherapies to promote neuroregeneration in the injured newborn brain

Olatz Arteaga Cabeza; Alkisti Mikrogeorgiou; Sujatha Kannan; Donna M Ferriero

doi:10.1016/j.addr.2019.10.005

Advanced nanotherapies to promote neuroregeneration in the injured newborn brain

Adv Drug Deliv Rev. 2019 Aug:148:19-37. doi: 10.1016/j.addr.2019.10.005. Epub 2019 Oct 31.

Authors

Olatz Arteaga Cabeza¹, Alkisti Mikrogeorgiou¹, Sujatha Kannan², Donna M Ferriero³

Affiliations

¹ Department of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA, United States.
² Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
³ Department of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA, United States; Department of Neurology, University of California San Francisco School of Medicine, San Francisco, CA, United States. Electronic address: donna.ferriero@ucsf.edu.

PMID: 31678359
DOI: 10.1016/j.addr.2019.10.005

Abstract

Neonatal brain injury affects thousands of babies each year and may lead to long-term and permanent physical and neurological problems. Currently, therapeutic hypothermia is standard clinical care for term newborns with moderate to severe neonatal encephalopathy. Nevertheless, it is not completely protective, and additional strategies to restore and promote regeneration are urgently needed. One way to ensure recovery following injury to the immature brain is to augment endogenous regenerative pathways. However, novel strategies such as stem cell therapy, gene therapies and nanotechnology have not been adequately explored in this unique age group. In this perspective review, we describe current efforts that promote neuroprotection and potential targets that are unique to the developing brain, which can be leveraged to facilitate neuroregeneration.

Keywords: Dendrimers; Gene therapy; Growth factors; Nanoparticles; Neurotrophic factors; PAMAM; Stem cells; Stroke.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Brain / drug effects*
Brain / pathology
Drug Delivery Systems
Humans
Infant, Newborn
Nanoparticles / chemistry*
Nanotechnology*
Nerve Regeneration / drug effects
Neuroprotective Agents / chemistry
Neuroprotective Agents / pharmacology*

Substances

Neuroprotective Agents