The aim of the study is to evaluate the clinical effect of primary suture anchors repair in the treatment of deltoid ligament rupture associated with ankle fractures. 34 patients with acute deltoid ligament rupture associated with ankle fractures were selected between 2011 and 2014. Medial clear space (MCS), American Orthopaedic Foot and Ankle Society (AOFAS) scores, visual analog scale (VAS) were noted. The mean follow-up was 28.4 (range, 22-35) months. The mean AOFAS score was 92.6 (range, 90-95) and the mean VAS score was 1.06±0.65 (range 0 to 2) points at the final follow-up. The mean MCS is (9.10±4.99) mm before and (3.71±0.33) mm after surgery in radiographs. At the postoperative final follow-up, the mean MCS of injured ankle is (3.74±0.32) mm in radiographs, and (3.65±0.17) mm of uninjured contralateral ankle. Using suture anchors for the primary repair of deltoid ligament rupture during the treatment of ankle fractures can achieve satisfactory outcomes.