Unusual cutaneous metastatic carcinoma

Ann Diagn Pathol. 2019 Dec:43:151399. doi: 10.1016/j.anndiagpath.2019.08.003. Epub 2019 Aug 12.

Abstract

Most of metastatic tumors to the skin are from primary tumors of the breast, lung, or from melanoma; metastases to the skin from primary carcinomas at other sites are rare. Cutaneous metastases of visceral carcinomas most often occur in patients with advanced disease, and are associated with a poor prognosis. We report 6 cases of nonmammary, nonpulmonary carcinoma metastatic to the skin. Most patients were elderly with advanced disease at the time of diagnosis of skin metastasis. The primary tumor sites included the thyroid, esophagus, biliary tract, ovary, and prostate. Awareness of these rare cases of metastasis to the skin will help pathologists and clinicians make the correct diagnosis.

Keywords: Carcinoma; Metastatic; Skin.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Bile Duct Neoplasms / metabolism
  • Bile Duct Neoplasms / pathology
  • Bile Duct Neoplasms / therapy
  • Breast Neoplasms / pathology
  • Carcinoma / secondary
  • Cholangiocarcinoma / metabolism
  • Cholangiocarcinoma / pathology
  • Cholangiocarcinoma / therapy
  • Diagnosis, Differential
  • Esophageal Neoplasms / metabolism
  • Esophageal Neoplasms / pathology
  • Esophageal Neoplasms / therapy
  • Fatal Outcome
  • Female
  • Humans
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / pathology*
  • Lung Neoplasms / secondary
  • Male
  • Melanoma / pathology
  • Middle Aged
  • Ovarian Neoplasms / metabolism
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / therapy
  • Prostatic Neoplasms / metabolism
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / therapy
  • Skin Neoplasms / pathology
  • Skin Neoplasms / secondary*
  • Thyroid Cancer, Papillary / pathology
  • Thyroid Cancer, Papillary / secondary*
  • Thyroid Cancer, Papillary / therapy
  • Thyroid Carcinoma, Anaplastic / pathology
  • Thyroid Carcinoma, Anaplastic / secondary*
  • Thyroid Carcinoma, Anaplastic / therapy