Atopic dermatitis (AD) is a chronic disease that impairs the patient's quality of life (QOL) given its impact on sleep, work productivity, emotional and mental health, physical activity, and social functioning. In this review, the most important findings about QOL in AD are summarized. We also aim to demonstrate the most commonly used methods for measuring QOL and to give practical advice on using these instruments in clinical practice and research. Furthermore, AD puts a great burden on patients, and the degree of this burden is related to disease severity.