Phytochemical investigation of the aerial parts of Perovskia abrotanoides (Lamiaceae) by normal phase column chromatography resulted in the isolation of perovskanol (1), a novel sesquiterpenoid possessing a 5/7/5 fused carbon ring skeleton. The structure of 1 was established by comprehensive spectroscopic data analysis including 1 D and 2 D NMR and HRESIMS. The antiprotozoal activity of compound 1 was evaluated against Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani, Plasmodium falciparum and no promising activities were shown against all parasite tested.
Keywords: Lamiaceae; Perovskia abrotanoides; perovskanol; sesquiterpenoid.