Biochemical properties and progress in cancers of tRNA-derived fragments

Zhongliang Ma; Jinbao Zhou; Yang Shao; Fatemah A Jafari; Pengfei Qi; Yanli Li

doi:10.1002/jcb.29492

Biochemical properties and progress in cancers of tRNA-derived fragments

J Cell Biochem. 2020 Mar;121(3):2058-2063. doi: 10.1002/jcb.29492. Epub 2019 Oct 31.

Authors

Zhongliang Ma¹, Jinbao Zhou¹, Yang Shao¹, Fatemah A Jafari¹, Pengfei Qi¹, Yanli Li¹

Affiliation

¹ Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai, China.

PMID: 31674076
DOI: 10.1002/jcb.29492

Abstract

tRNA-derived small RNAs (tRFs), a kind of noncoding RNAs, are generated from transfer RNAs. tRFs have some types according to their source and sizes. They play important roles in cell life and carcinogenesis. In this paper, we review the biogenesis and biological properties. We also focus on current progress of tRFs and some tsRNAs such as tRF-Leu-CAG, which have been studied or will be further investigated in tumorgenesis and diagnostic biomarkers in the clinic.

Keywords: noncoding RNA; tRNA-derived fragments; transfer RNA; tumorgenesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Gene Expression Regulation, Neoplastic*
Humans
Neoplasms / genetics*
Neoplasms / metabolism
Neoplasms / pathology*
RNA Precursors / genetics*
RNA Precursors / metabolism
RNA, Transfer / genetics*
RNA, Transfer / metabolism

Substances

RNA Precursors
RNA, Transfer