Effects of glucocerebrosidase gene polymorphisms and mutations on the risk of Parkinson's disease dementia: A meta-analysis

Yingyu Zhang; Jiajun Chen; Chuan Xu; Jingqi Feng; Jia Li

doi:10.1016/j.neulet.2019.134544

Effects of glucocerebrosidase gene polymorphisms and mutations on the risk of Parkinson's disease dementia: A meta-analysis

Neurosci Lett. 2020 Jan 1:714:134544. doi: 10.1016/j.neulet.2019.134544. Epub 2019 Oct 28.

Authors

Yingyu Zhang¹, Jiajun Chen¹, Chuan Xu¹, Jingqi Feng¹, Jia Li²

Affiliations

¹ Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.
² Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China. Electronic address: lijia33233@jlu.edu.cn.

PMID: 31672490
DOI: 10.1016/j.neulet.2019.134544

Abstract

Objective: Exploring the impact of glucocerebrosidase gene (GBA) polymorphisms and mutations on the pathogenesis of Parkinson's disease dementia (PDD) plays an important role in the diagnosis and treatment of this disease. This meta-analysis aimed to investigate the effects of GBA polymorphisms and mutations on the risk of PDD and to identify the relationship between GBA genotype and PDD.

Methods: A computer-based search was performed to retrieve publications from PubMed, Cochrane library, Embase, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, and Wanfang databases using the search terms "glucocerebrosidase", "Parkinson's disease", and "dementia". After rigorous screening, cohort studies were included for meta-analysis.

Results: The risk of PDD in GBA variant carriers was 1.94 times that in non-carriers (hazard ratio [HR], 1.94; 95% confidence interval [CI], 1.53-2.46). The risk of PDD in GBA polymorphism carriers was 1.87 times that in non-carriers (HR, 1.87; 95% CI, 1.18-2.98). The risk of PDD in GBA mutation carriers was 3.64 times that in non-carriers (HR, 3.64; 95% CI, 2.74-4.83). The risk of PDD in p.L444P variant carriers (HR, 4.81; 95% CI, 3.37-6.86) was significantly higher than that in p.N370S variant carriers (HR, 1.95; 95% CI, 1.29-1.94).

Conclusion: GBA polymorphisms and mutations are potential risk factors for PDD.

Keywords: Glucocerebrosidase; Meta-analysis; Parkinson’s disease dementia; p.L444P; p.N370S.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Genetic Predisposition to Disease / genetics*
Glucosylceramidase / genetics*
Humans
Mutation*
Parkinson Disease / genetics*
Polymorphism, Genetic / genetics*

Substances

Glucosylceramidase