Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas

Natalie Patel; Andrea Barbieri; Joanna Gibson

doi:10.1016/j.path.2019.08.007

Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas

Surg Pathol Clin. 2019 Dec;12(4):1021-1044. doi: 10.1016/j.path.2019.08.007.

Authors

Natalie Patel¹, Andrea Barbieri², Joanna Gibson³

Affiliations

¹ Gastrointestinal and Pancreaticobiliary Pathology, Department of Pathology, Yale School of Medicine, Yale New Haven Hospital, 20 York Street, New Haven, CT 06510, USA.
² Department of Pathology, Yale School of Medicine, Yale New Haven Hospital, 20 York Street, EP2-608, New Haven, CT 06510, USA.
³ Department of Pathology, Yale School of Medicine, Yale New Haven Hospital, 20 York Street, EP2-610, New Haven, CT 06510, USA. Electronic address: joanna.gibson@yale.edu.

PMID: 31672292
DOI: 10.1016/j.path.2019.08.007

Abstract

Neuroendocrine neoplasms (NENs) of the gastrointestinal (GI) tract and pancreas are a rare and heterogeneous group of neoplasms characterized by common cellular features as well as unique site-specific traits. GI and pancreatic NENs are much rarer than the more common adenocarcinomas arising at these sites. However, the incidences of GI and pancreatic NENs have increased significantly, particularly in the stomach and common site, followed by rectum, appendix, colon, and stomach. Pancreatic NENs are also uncommon, with fewer than 1 per 100,000, accounting for 1% to 2% of all pancreatic neoplasms.

Keywords: Ki-67; Poorly differentiated neuroendocrine carcinoma; WHO classification and grade; Well-differentiated neuroendocrine tumor.

Publication types

Review

MeSH terms

Cell Differentiation
Cell Proliferation
Humans
Immunohistochemistry
Incidence
Neuroendocrine Tumors / mortality
Neuroendocrine Tumors / pathology*
Pancreatic Neoplasms / mortality
Pancreatic Neoplasms / pathology*
Prognosis
Stomach Neoplasms / mortality
Stomach Neoplasms / pathology*