Virescenosides From the Holothurian-Associated Fungus Acremonium Striatisporum Kmm 4401

Olesya I Zhuravleva; Alexandr S Antonov; Galina K Oleinikova; Yuliya V Khudyakova; Roman S Popov; Vladimir A Denisenko; Evgeny A Pislyagin; Ekaterina A Chingizova; Shamil Sh Afiyatullov

doi:10.3390/md17110616

Virescenosides From the Holothurian-Associated Fungus Acremonium Striatisporum Kmm 4401

Mar Drugs. 2019 Oct 29;17(11):616. doi: 10.3390/md17110616.

Authors

Olesya I Zhuravleva^{1

2}, Alexandr S Antonov³, Galina K Oleinikova⁴, Yuliya V Khudyakova⁵, Roman S Popov⁶, Vladimir A Denisenko⁷, Evgeny A Pislyagin⁸, Ekaterina A Chingizova⁹, Shamil Sh Afiyatullov¹⁰

Affiliations

¹ Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. zhuravleva.oi@dvfu.ru.
² Affiliation School of Natural Science, Far Eastern Federal University, Sukhanova St., 8, 690000 Vladivostok, Russia. zhuravleva.oi@dvfu.ru.
³ Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. pibocfebras@gmail.com.
⁴ Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. oleingk@mail.ru.
⁵ Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. 161070@rambler.ru.
⁶ Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. prs_90@mail.ru.
⁷ Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. vladenis@pidoc.dvo.ru.
⁸ Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. pislyagin@hotmail.com.
⁹ Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. martyyas@mail.ru.
¹⁰ Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia. afiyat@piboc.dvo.ru.

Abstract

Ten new diterpene glycosides virescenosides Z₉-Z₁₈ (1-10) together with three known analogues (11-13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassium bromide. Structures of the isolated metabolites were established based on spectroscopic methods. The effects of some isolated glycosides and aglycons 15-18 on urease activity and regulation of Reactive Oxygen Species (ROS) and Nitric Oxide (NO) production in macrophages stimulated with lipopolysaccharide (LPC) were evaluated.

Keywords: Acremonium striatisporum; diterpene glycosides; marine fungi; secondary metabolites; urease activity.

MeSH terms

Acremonium / chemistry*
Animals
Diterpenes / chemistry*
Diterpenes / isolation & purification
Fungi
Glycosides / chemistry*
Glycosides / isolation & purification
Glycosides / pharmacology*
Holothuria / microbiology
Lipopolysaccharides
Macrophages / drug effects*
Mice
Molecular Structure
Nitric Oxide
Reactive Oxygen Species
Urease / drug effects

Substances

Diterpenes
Glycosides
Lipopolysaccharides
Reactive Oxygen Species
Nitric Oxide
Urease

Grants and funding

19-74-10014/Russian Science Foundation