Very different from enantiorecognition at an analytical level, preparative enantioseparation at scale production has to confront many problems. In recent years, various separation techniques have been developed with much progress including high-performance liquid chromatography, liquid-liquid extraction, membrane separation, enantioselective solid-phase absorption, and enantioselective precipitation. Among them, in order to achieve high enantiomerical purity of the enantiomers after separation, two approaches are commonly carried out. One is that continuous separation is necessary when one-step separation cannot have satisfactory efficiency. Another is that most of the research groups focus on the construction of novel chiral environment with much more rigid structures of the selectors. Combined with these two aspects, we mainly introduce current topics, trends, strategies related to enantioseparation under large scale.
Keywords: chiral selectors; enantioseparation; racemate; scale production.
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