High-field NMR with dissolution triplet-DNP

Akinori Kagawa; Koichiro Miyanishi; Naoki Ichijo; Makoto Negoro; Yushi Nakamura; Hideo Enozawa; Tsuyoshi Murata; Yasushi Morita; Masahiro Kitagawa

doi:10.1016/j.jmr.2019.106623

High-field NMR with dissolution triplet-DNP

J Magn Reson. 2019 Dec:309:106623. doi: 10.1016/j.jmr.2019.106623. Epub 2019 Oct 19.

Authors

Akinori Kagawa¹, Koichiro Miyanishi², Naoki Ichijo², Makoto Negoro³, Yushi Nakamura⁴, Hideo Enozawa⁴, Tsuyoshi Murata⁴, Yasushi Morita⁴, Masahiro Kitagawa⁵

Affiliations

¹ Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan; Quantum Information and Quantum Biology Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Japan; PRESTO, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan. Electronic address: kagawa@ee.es.osaka-u.ac.jp.
² Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan.
³ Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan; Quantum Information and Quantum Biology Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Japan; PRESTO, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan.
⁴ Faculty of Engineering, Aichi Institute of Technology, Toyota, Aichi 470-0392, Japan.
⁵ Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan; Quantum Information and Quantum Biology Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Japan.

PMID: 31669795
DOI: 10.1016/j.jmr.2019.106623

Abstract

Dissolution dynamic nuclear polarization (DNP) has wide variety of important applications such as real-time monitoring of chemical reactions and metabolic imaging. We construct DNP using photoexcited triplet electron spins (Triplet-DNP) apparatus combined with dissolution apparatus for solution NMR in a high magnetic field. Triplet-DNP enables us to obtain high nuclear polarization at room temperature. Solid-state samples polarized by Triplet-DNP are transferred to a superconducting magnet and dissolved by injecting aqueous solvents. The ¹³C polarization of 0.22% has been obtained for [caryboxy-¹³C]benzoic acid-d in the liquid state. Our results show that Triplet-DNP can be applied to real-time monitoring with solution NMR.

Keywords: Dissolution-DNP; High polarization; Triplet electron spin.

Publication types

Research Support, Non-U.S. Gov't