Energy Trade-offs in Host Defense: Immunology Meets Physiology

Trends Endocrinol Metab. 2019 Dec;30(12):875-878. doi: 10.1016/j.tem.2019.08.012. Epub 2019 Oct 25.

Abstract

Host defense relies not only on microbicidal mechanisms (resistance), but also on management of collateral damage (tolerance). Here, we discuss how this immunology concept converges with a physiology-born theory on the dichotomy of thermometabolic responses in infection (fever versus hypothermia), yielding a model of immunity that transcends discipline barriers.

Keywords: fever; hypothermia; immunity; inflammation; resistance; tolerance.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Fever / immunology
  • Fever / metabolism
  • Fever / physiopathology
  • Humans
  • Hypothermia / immunology
  • Hypothermia / metabolism
  • Hypothermia / physiopathology
  • Immunity / physiology*
  • Inflammation / immunology*
  • Inflammation / metabolism
  • Inflammation / physiopathology*