Induction of membrane curvature by proteins involved in Golgi trafficking

Stefanie L Makowski; Ramya S Kuna; Seth J Field

doi:10.1016/j.jbior.2019.100661

Induction of membrane curvature by proteins involved in Golgi trafficking

Adv Biol Regul. 2020 Jan:75:100661. doi: 10.1016/j.jbior.2019.100661. Epub 2019 Oct 16.

Authors

Stefanie L Makowski¹, Ramya S Kuna¹, Seth J Field²

Affiliations

¹ Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA, 92093, USA.
² Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA, 92093, USA. Electronic address: sjfield@ucsd.edu.

Abstract

The Golgi apparatus serves a key role in processing and sorting lipids and proteins for delivery to their final cellular destinations. Vesicle exit from the Golgi initiates with directional deformation of the lipid bilayer to produce a bulge. Several mechanisms have been described by which lipids and proteins can induce directional membrane curvature to promote vesicle budding. Here we review some of the mechanisms implicated in inducing membrane curvature at the Golgi to promote vesicular trafficking to various cellular destinations.

Keywords: GOLPH3; Golgi; Membrane curvature; Phosphoinositides; Trafficking; Vesicle budding.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Golgi Apparatus / pathology*
Humans
Lipid Bilayers / metabolism*
Membrane Proteins / metabolism*
Phosphatidylinositol Phosphates / metabolism
Protein Transport / physiology
Transport Vesicles

Substances

Lipid Bilayers
Membrane Proteins
Phosphatidylinositol Phosphates

Abstract

Publication types

MeSH terms

Substances

Grants and funding