Background: The prognostic predictors of pulmonary hypertension (PH) due to advanced heart failure (HF) have yet to be explored.
Objectives: To examine the prognostic value of hemodynamics and comorbidities in this patient group.
Methods: We retrospectively enrolled consecutive patients with PH due to advanced HF diagnosed by echocardiography and right heart catheterization. Follow-up was performed every 6 months ± 2 weeks. Primary endpoints were all-cause mortality and heart or lung transplantation.
Results: In total, 92 patients were included. The mean age was 46.82 years and mean left ventricular ejection fraction (LVEF) was 26.63%. During a median follow-up time of 9.72 months, 66 patients (71.7%) met primary endpoints. Pulmonary arterial compliance (PAC) was a significant predictor for primary endpoints and patients burdened with more than 3 comorbidities had worse prognoses (P = 0.0114).
Conclusions: In these patients, PAC can be a potential prognostic predictor and patients with a higher comorbidity burden have worse outcomes.
Keywords: Comorbidity; Prognosis; Pulmonary arterial compliance; Survival.
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