Prognostic value of hemodynamics and comorbidities in pulmonary hypertension due to advanced heart failure

Heart Lung. 2020 Mar-Apr;49(2):158-164. doi: 10.1016/j.hrtlng.2019.10.003. Epub 2019 Oct 23.

Abstract

Background: The prognostic predictors of pulmonary hypertension (PH) due to advanced heart failure (HF) have yet to be explored.

Objectives: To examine the prognostic value of hemodynamics and comorbidities in this patient group.

Methods: We retrospectively enrolled consecutive patients with PH due to advanced HF diagnosed by echocardiography and right heart catheterization. Follow-up was performed every 6 months ± 2 weeks. Primary endpoints were all-cause mortality and heart or lung transplantation.

Results: In total, 92 patients were included. The mean age was 46.82 years and mean left ventricular ejection fraction (LVEF) was 26.63%. During a median follow-up time of 9.72 months, 66 patients (71.7%) met primary endpoints. Pulmonary arterial compliance (PAC) was a significant predictor for primary endpoints and patients burdened with more than 3 comorbidities had worse prognoses (P = 0.0114).

Conclusions: In these patients, PAC can be a potential prognostic predictor and patients with a higher comorbidity burden have worse outcomes.

Keywords: Comorbidity; Prognosis; Pulmonary arterial compliance; Survival.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cardiac Catheterization
  • Comorbidity
  • Echocardiography
  • Female
  • Heart Failure / physiopathology*
  • Hemodynamics
  • Humans
  • Hypertension, Pulmonary / physiopathology*
  • Male
  • Middle Aged
  • Prognosis
  • Pulmonary Artery
  • Retrospective Studies
  • Stroke Volume
  • Ventricular Function, Left*