Reclassifying Pseudopolyps in Inflammatory Bowel Disease: Histologic and Endoscopic Description in the New Era of Mucosal Healing

Mona Rezapour; Maria Alejandra Quintero; Nidah S Khakoo; Daniel A Sussman; Jodie A Barkin; Jennifer Clarke; Tanya Varma; Amar R Deshpande; David H Kerman; Oriana Damas; Maria T Abreu

doi:10.1093/crocol/otz033

Reclassifying Pseudopolyps in Inflammatory Bowel Disease: Histologic and Endoscopic Description in the New Era of Mucosal Healing

Crohns Colitis 360. 2019 Oct;1(3):otz033. doi: 10.1093/crocol/otz033. Epub 2019 Oct 15.

Affiliations

¹ Department of Gastroenterology and Hepatology, University of California Los Angeles, Los Angeles, California.
² Department of Gastroenterology and Hepatology, University of Miami, Miami, Florida.
³ Department of Medicine, University of Miami, Miami, Florida.
⁴ Nebraska Food for Health Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska.
⁵ Ameripath, Shreveport, Louisiana.

Abstract

Introduction: In this study, we identify the frequency of pseudopolyps (PPs) with normal histology and their association to surrounding tissue.

Methods: Patients were enrolled in a study identifying endoscopic characteristics of PPs (n = 29) or were collected as part of our IBD biobank (n = 16). Statistical analysis included Stata v.15.0. chi-square and Student t-test.

Results: A total of 45 patients with 117 PP biopsies were identified. More patients with healed PP were in endoscopic remission compared with those with inflammatory PP (82.6% vs 17.4%, respectively).

Conclusion: This is the first study to find mucosal healing of PPs and its association with deep remission.

Keywords: healed pseudopolyps; inflammatory bowel disease; inflammatory pseudopolyps.

Grants and funding

K23 DK117054/DK/NIDDK NIH HHS/United States