Synthesis of new water-soluble ionic liquids and their antibacterial profile against gram-positive and gram-negative bacteria

Ali Niyazi Duman; Ismail Ozturk; Ayça Tunçel; Kasim Ocakoglu; Suleyman Gokhan Colak; Mine Hoşgör-Limoncu; Fatma Yurt

doi:10.1016/j.heliyon.2019.e02607

Synthesis of new water-soluble ionic liquids and their antibacterial profile against gram-positive and gram-negative bacteria

Heliyon. 2019 Oct 10;5(10):e02607. doi: 10.1016/j.heliyon.2019.e02607. eCollection 2019 Oct.

Authors

Ali Niyazi Duman¹, Ismail Ozturk², Ayça Tunçel³, Kasim Ocakoglu⁴, Suleyman Gokhan Colak⁴, Mine Hoşgör-Limoncu⁵, Fatma Yurt^{1

3}

Affiliations

¹ Department of Material Science and Engineering, Ege University, Bornova, Izmir, 35100, Turkey.
² Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Izmir Katip Celebi University, Cigli, Izmir, 35620, Turkey.
³ Institute of Nuclear Science, Department of Nuclear Applications, Ege University, Bornova, Izmir, 35100, Turkey.
⁴ Department of Energy Systems Engineering, Faculty of Technology, Tarsus University, Tarsus, TR-33480, Turkey.
⁵ Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Ege University, Bornova, Izmir, 35100, Turkey.

Abstract

A series of imidazolium bromide salts (NIM-Br 1a, 1b and 1c) bearing different lengths of alkyl chains were synthesized and theirin vitro antibacterial activities were determined by measuring the minimum inhibitory concentration (MIC) values for Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Enterococcus faecalis. In addition, these imidazolium derivatives were also evaluated against biofilm produced by these bacterial strains. All compounds were found to be effective against Gram-positive and Gram-negative bacteria, and also more effective on the S. aureus biofilm production than the others.

Keywords: Antibacterial activity; Antibiofilm effect; Bacteria; Biofilms; Imidazolium cation; Imidazolium salt; Inorganic chemistry; Ionic liquids; Microorganism; Organic chemistry.