Proteome dataset of subcutaneous adipose tissue from postpartum cows treated with sodium salicylate

Caio Takiya; Shawnee Montgomery; Laman Mamedova; Gitit Kra; Nataly Nemes-Navon; Yishai Levin; Sherry Fleming; Barry Bradford; Maya Zachut

doi:10.1016/j.dib.2019.104567

Proteome dataset of subcutaneous adipose tissue from postpartum cows treated with sodium salicylate

Data Brief. 2019 Sep 26:26:104567. doi: 10.1016/j.dib.2019.104567. eCollection 2019 Oct.

Authors

Caio Takiya¹, Shawnee Montgomery¹, Laman Mamedova¹, Gitit Kra², Nataly Nemes-Navon^{2

3}, Yishai Levin⁴, Sherry Fleming⁵, Barry Bradford¹, Maya Zachut²

Affiliations

¹ Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506, United States.
² Department of Ruminant Science, Institute of Animal Sciences Agricultural Research Organization/Volcani Center, Rishon Lezion 7505101, Israel.
³ Department of Animal Science, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.
⁴ The Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot 7610001, Israel.
⁵ Division of Biology, Kansas State University, Manhattan 66506, United States.

Abstract

This article contains raw and processed data related to research published by Takiya et al. [1]. Literature have shown that treatment with the nonsteroidal anti-inflammatory agent sodium salicylate (SS) during the first days postpartum in dairy cows increased lactation performance [2], and tended to alter glucose metabolism [3]. Yet, the specific effects of systemic SS treatment on the proteome of the adipose tissue (AT) and on the inflammatory process in AT of postpartum cows is unknown. Subcutaneous AT samples were collected at 7 d of lactation from control cows (n = 5) and from cows treated with 2.3 g/L SS (n = 5) via drinking water during the first 7 d of lactation. Protein extraction and liquid chromatography-mass spectrometry were performed to obtain proteomics data. Differential abundance of proteins was determined through MS1 intensity based label-free method. Proteomics analysis generated a novel dataset consisted of 1422 proteins, 80 (5.6%) of which were differentially abundant [fold change ± 1.5, P < 0.05 2-way ANOVA] when comparing control and SS-treated cows. The present dataset of subcutaneous AT proteome from postpartum dairy cows treated with SS can be used as a reference for any research involving nonsteroidal anti-inflammatory agent treatment in dairy cows or in comparative research between species.

Keywords: Adipose tissue; Inflammation; Non-steroidal anti-inflammatory drug; Proteomics; Transition period.