Dataset on the effect of knockout of KLK8 in social memory

Hitomi Nakazawa; Yuka Suzuki; Yasuyuki Ishikawa; Yoshio Bando; Shigetaka Yoshida; Sadao Shiosaka

doi:10.1016/j.dib.2019.104458

Dataset on the effect of knockout of KLK8 in social memory

Data Brief. 2019 Aug 30:26:104458. doi: 10.1016/j.dib.2019.104458. eCollection 2019 Oct.

Authors

Hitomi Nakazawa¹, Yuka Suzuki², Yasuyuki Ishikawa², Yoshio Bando³, Shigetaka Yoshida¹, Sadao Shiosaka⁴

Affiliations

¹ Department of Functional Anatomy and Neuroscience, Asahikawa Medical University, Asahikawa, Hokkaido, 078-8510, Japan.
² Department of Systems Life Engineering, Maebashi Institute of Technology, Maebashi, Gunma, 371-0816, Japan.
³ Department of Anatomy, Akita University Graduate School of Medicine, Akita, Akita, 010-8543, Japan.
⁴ Emeritus Professor of Graduate School of Biological Science, Nara Institute of Science and Technology (NAIST), Ikoma, Nara, 630-0192, Japan.

Abstract

The data presented in this article have been produced as supporting data of the original research article titled "Impaired social discrimination behavior despite normal social approach by kallikrein-related peptidase 8 knockout mouse" (Nakazawa et al., 2019). Sociability and recognition of conspecifics and discrimination among conspecifics (social memory) is fundamental for pair bonding, to create social hierarchy, and eventually establish affiliated societies in social animals, including humans. It has been speculated that the processes of cognition, attention and memory, which are largely mediated by the hippocampus, contribute to social behavior. However, the molecular basis of social behavior remains elusive. This article presents a dataset of behavior-related KLK8-NRG1-ErbB signaling changes in the hippocampus and the effect of activation of ErbB signaling on social behavior.