This study aims to explore the diagnostic value of specific immunoglobulin E (sIgE) and specific immunoglobulin G (sIgG) of Aspergillus fumigatus in the diagnosis of allergic broncho-pulmonary aspergillosis (ABPA) and severe asthma with fungal sensitization (SAFS). A total of 17 ABPA patients and 14 SAFS patients were enrolled. The levels of sIgG [2 294.00 (1 527.00, 14 170.00) U/ml vs. 972.60 (650.90, 1 792.00) U/ml] and sIgE [8.77 (1.64, 16.85) kU/L vs. 1.04 (0.70, 2.05) kU/L] in ABPA patients were significantly higher than those in SAFS patients (P<0.05). Aspergillus fumigatus sIgG was strongly correlated with Aspergillus fumigatus sIgE (r(s)=0.797, P<0.001) in ABPA patients. When combined with Aspergillus fumigatus sIgG (>1 000.00 U/mL) and Aspergillus fumigatus sIgE (>1.00 kU/L), the sensitivity was 82.3% and specificity 78.6% for the differential diagnosis of ABPA and SAFS. It demonstrates the diagnostic value of Aspergillus fumigatus sIgG and sIgE.
探讨变应性支气管肺曲霉病（ABPA）和真菌致敏性重症支气管哮喘（SAFS）患者的致敏与诊断。选17例ABPA患者和14例SAFS患者，检测患者血烟曲霉特异性IgG、IgE。结果显示，ABPA患者烟曲霉特异性IgG和IgE水平高于SAFS患者[IgG:2 294.00 (1 527.00, 14 170.00)U/ml比972.60 (650.90, 1 792.00)U/ml; IgE：8.77 (1.64, 16.85)kU/L比1.04(0.70, 2.05)kU/L；P值均<0.05]。相关性分析显示，ABPA患者烟曲霉特异性IgG与特异性IgE有相关性（r(s)=0.797, P<0.001），而在SAFS患者中无显著相关。接受者操作特征（ROC）曲线分析显示，联合烟曲霉特异性IgG≥1 000.00 U/ml和特异性IgE≥1.00 kU/L鉴别诊断ABPA与SAFS时敏感度为82.3%，特异度为78.6%，具有临床应用价值。.
Keywords: Aspergillosis, allergic bronchopulmonary; Asthma; Immunoglobulin IgE; Immunoglobulin IgG.