A Lethal Aerosol Exposure Model of Nipah Virus Strain Bangladesh in African Green Monkeys

Abhishek N Prasad; Krystle N Agans; Satheesh K Sivasubramani; Joan B Geisbert; Viktoriya Borisevich; Chad E Mire; William S Lawrence; Karla A Fenton; Thomas W Geisbert

doi:10.1093/infdis/jiz469

A Lethal Aerosol Exposure Model of Nipah Virus Strain Bangladesh in African Green Monkeys

J Infect Dis. 2020 May 11;221(Suppl 4):S431-S435. doi: 10.1093/infdis/jiz469.

Authors

Abhishek N Prasad^{1

2}, Krystle N Agans^{1

2}, Satheesh K Sivasubramani^{1

2}, Joan B Geisbert^{1

2}, Viktoriya Borisevich^{1

2}, Chad E Mire^{1

2}, William S Lawrence^{1

2}, Karla A Fenton^{1

2}, Thomas W Geisbert^{1

2}

Affiliations

¹ Galveston National Laboratory, Galveston, Texas, USA.
² Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.

PMID: 31665351
DOI: 10.1093/infdis/jiz469

Abstract

The high case-fatality rates and potential for use as a biological weapon make Nipah virus (NiV) a significant public health concern. Previous studies assessing the pathogenic potential of NiV delivered by the aerosol route in African green monkeys (AGMs) used the Malaysia strain (NiVM), which has caused lower instances of respiratory illness and person-to-person transmission during human outbreaks than the Bangladesh strain (NiVB). Accordingly, we developed a small particle aerosol model of NiVB infection in AGMs. Consistent with other mucosal AGM models of NiVB infection, we achieved uniform lethality and disease pathogenesis reflective of that observed in humans.

Keywords: aerosol; Nipah virus; animal model; pathogenesis; primate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aerosols
Animals
Henipavirus Infections / pathology
Henipavirus Infections / virology*
Nipah Virus / classification*
Nipah Virus / physiology*

Substances

Aerosols