Cucurbit[8]uril-based supramolecular nanocapsules with a multienzyme-cascade antioxidative effect

Chem Commun (Camb). 2019 Nov 14;55(92):13820-13823. doi: 10.1039/c9cc07085k.

Abstract

A supramolecular nanocapsule was constructed by the ternary host-guest complexation of azobenzene (Azo) and methylviologen (MV) to cucurbit[8]uril (CB[8]) and the subsequent self-assembly. The supramolecular nanocapsule with both glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities can mimic the intracellular enzymatic reactive oxygen species (ROS) defense system.

MeSH terms

  • 3T3 Cells
  • Animals
  • Antioxidants / chemistry*
  • Azo Compounds / chemistry
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / metabolism
  • Bridged-Ring Compounds / chemistry*
  • Cell Survival / drug effects
  • Glutathione Peroxidase / chemistry
  • Glutathione Peroxidase / metabolism
  • Imidazoles / chemistry*
  • Mice
  • Microscopy, Confocal
  • Nanocapsules / chemistry*
  • Nanocapsules / toxicity
  • Paraquat / chemistry
  • Reactive Oxygen Species / chemistry
  • Superoxide Dismutase / chemistry
  • Superoxide Dismutase / metabolism

Substances

  • Antioxidants
  • Azo Compounds
  • Biocompatible Materials
  • Bridged-Ring Compounds
  • Imidazoles
  • Nanocapsules
  • Reactive Oxygen Species
  • cucurbit(8)uril
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • azobenzene
  • Paraquat