Abstract
A supramolecular nanocapsule was constructed by the ternary host-guest complexation of azobenzene (Azo) and methylviologen (MV) to cucurbit[8]uril (CB[8]) and the subsequent self-assembly. The supramolecular nanocapsule with both glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities can mimic the intracellular enzymatic reactive oxygen species (ROS) defense system.
MeSH terms
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3T3 Cells
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Animals
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Antioxidants / chemistry*
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Azo Compounds / chemistry
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Biocompatible Materials / chemistry
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Biocompatible Materials / metabolism
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Bridged-Ring Compounds / chemistry*
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Cell Survival / drug effects
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Glutathione Peroxidase / chemistry
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Glutathione Peroxidase / metabolism
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Imidazoles / chemistry*
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Mice
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Microscopy, Confocal
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Nanocapsules / chemistry*
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Nanocapsules / toxicity
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Paraquat / chemistry
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Reactive Oxygen Species / chemistry
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Superoxide Dismutase / chemistry
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Superoxide Dismutase / metabolism
Substances
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Antioxidants
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Azo Compounds
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Biocompatible Materials
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Bridged-Ring Compounds
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Imidazoles
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Nanocapsules
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Reactive Oxygen Species
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cucurbit(8)uril
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Glutathione Peroxidase
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Superoxide Dismutase
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azobenzene
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Paraquat