Human iPSC banking: barriers and opportunities

J Biomed Sci. 2019 Oct 28;26(1):87. doi: 10.1186/s12929-019-0578-x.

Abstract

The introduction of induced pluripotent stem cells (iPSCs) has opened up the potential for personalized cell therapies and ushered in new opportunities for regenerative medicine, disease modeling, iPSC-based drug discovery and toxicity assessment. Over the past 10 years, several initiatives have been established that aim to collect and generate a large amount of human iPSCs for scientific research purposes. In this review, we compare the construction and operation strategy of some iPSC banks as well as their ongoing development. We also introduce the technical challenges and offer future perspectives pertaining to the establishment and management of iPSC banks.

Keywords: Cell bank; Induced pluripotent stem cell (iPSC); Personalized medicine.

Publication types

  • Review

MeSH terms

  • Biological Specimen Banks*
  • Cell- and Tissue-Based Therapy / methods*
  • Humans
  • Induced Pluripotent Stem Cells*
  • Regenerative Medicine / methods*
  • Stem Cell Transplantation